Scientific Papers, Books, Book Chapters, and Dissertations

95. Protamines of the spider Steatoda sp. provide an example of liquid-liquid phase separation chromatin transitions during spermiogenesis

Development. In press. (IF = 3.70)

Leyden M.R., Michalik P., Baruffaldi L., Mahmood S., Kalani L., Hunt D.F., Eirin-Lopez J.M., Andrade M.C.B., Shabanowitz J., and Ausió J.

94. Ecological forensic testing: Using multiple primers for eDNA detection of marine vertebrates in an estuarine lagoon subject to anthropogenic influences

Gene 928:148720. Jul. 2024 (IF = 3.50)

Chiquillo K.*, Wong J.*, and Eirin-Lopez J.

93. Protamines and the sperm nuclear basic proteins Pandora’s Box of Insects.

Biochemistry and Cell Biology 102:238-251. Mar. 2024 (IF = 2.90)

Leyden M.R., Gowen B., Gonzalez-Romero R., Eirin-Lopez J.M., Kim B.H., Hayashi F. McCartney J., Zhang P.C., Kubo-Irie M., Shabanowitz J., Hunt D.F., Ferree P., Kasinsky H., and Ausio J.

Dissertation — Evaluating the capacity and molecular underpinnings of phenotypic plasticity and environmental memory in Caribbean Acropora corals

Ph.D. in Biology, Florida International University

Serena N. Hackerott

92. Multi-omic characterization of mechanisms contributing to rapid phenotypic plasticity in the coral Acropora cervicornis under divergent environments.

Coral Reefs in press. Nov. 2023 (IF = 3.80, Q1)

Rodriguez-Casariego J.*, Mercado-Molina A., Soledade Lemos L., Soares Quinete N., Bellantuono A., Rodriguez-Lanetty M., Sabat A., and Eirin-Lopez J.M.

91. Relationships between phenotypic plasticity and epigenetic variation in two Caribbean Acropora corals.

Molecular Ecology 32:4814-4828. Oct. 2023 (IF = 6.62, Q1)

Hackerott S.**, Virdis F., Flood P.J., Garcia-Souto D., Paez W., and Eirin-Lopez J.M.

90. Age Group DNA Methylation Differences in Lemon Sharks (Negaprion brevirostris): Implications for future age estimation tools

Ecology and Evolution 12:e9226. Sep. 2022 (IF = 2.91, Q1)

Beal A.**, Hackerott S.**, Feldheim K., Gruber S.H., and Eirin-Lopez J.

89. Coral-bleaching responses to climate change across biological scales

Global Change Biology 28:4229-4250. Apr. 2022 (IF = 10.86, Q1)

van Woesik R., Shlesinger T., Grottoli A.G., Toonen R.J., Vega Thurber R., Warner M.E., Hulver A.M., Chapron L., McLachlan R.H., Albright R., Crandall E., DeCarlo T.M., Donovan M.K., Eirin-Lopez J.M., Harrison H.B., Heron S.F., Huang D., Humanes A., Krueger T., Madin J.S., Manzello D., McManus L.C., Matz M., Muller E.M., Rodriguez-Lanetty M., Vega-Rodriguez M., Voolstra C.R., and Zaneveld J.

88. Editorial: Adaptation and Phenotypic Plasticity to Climate Change

Frontiers in Marine Science. Apr. 2022 (IF = 4.43, Q1)

Shama L.N.S., Donelson J.M., Eirin-Lopez J.M., and Ravasi T.

87. Symbiont shuffling induces differential DNA methylation responses to thermal stress in the coral Montastraea cavernosa.

Molecular Ecology 31:588-602. Jan. 2022 (IF = 6.18, Q1)

Rodriguez-Casariego J.**, Cunning R., Baker A., and Eirin-Lopez J.M.

86. Invertebrate methylomes provide insight into mechanisms of environmental tolerance and reveal methodological biases

Molecular Ecology Resources 22:1247-1261. Jan. 2022 (IF = 7.09, Q1)

Trigg S., Venkataraman Y.R., Gavery M.R., Roberts S.B., Bhattacharya D., Downey-Wall A., Eirin-Lopez J.M., Johnson K.M., Lottheros K.E., Puritz J., and Putnam H.

85. Evolution of methyltransferase like (METTL) proteins in Metazoa: A complex gene family involved in epitranscriptomic regulation and other epigenetic processes

Molecular Biology and Evolution 38:5309-5327. Sep. 2021 (IF = 16.24, Q1)

Wong J.*, and Eirin-Lopez J.M.

84. Evolution of a histone variant involved in compartmental regulation of NAD metabolism

Nature Structural and Molecular Biology 28:1009-1019. Sep. 2021 (IF = 15.37, Q1)

Guberovic I., Hurtado-Bagès S., Rivera-Casas C.*, Knobloch G., Malinverni R., Valero V., Leger M.M., García J., Basquin J., Gómez de Cedrón M., Frigolé-Vivas M., Cheema M.S., Pérez A., Ausio J., Ramírez de Molina A., Salvatella X., Ruiz-Trillo I., Eirin-Lopez J., Ladurner A.G., Buschbeck M.

83. Coral environmental memory: Causes, mechanisms, and consequences for future reefs

Trends in Ecology and Evolution 36:1011-1023. Aug. 2021 (IF = 17.71, Q1)

Hackerott S.H.**, Martell H.A., and Eirin-Lopez J.M.

82. Epigenetic responses in juvenile Lemon sharks (Negaprion brevirostris) during a coastal dredging episode in Bimini, Bahamas

Ecological Indicators 127:107793. Apr. 2021. (IF = 4.23, Q1)

Beal A.P.**, Hackerott S.H.**, Franks B., Gruber S., Feldheim K., and Eirin-Lopez J.M.

81. Editorial: Marine Environmental Epigenetics

Frontiers in Marine Sciences. Apr. 2021. (IF = 3.66, Q1)

Eirin-Lopez J.M., and Putnam H.

Dissertation — Epigenetic Mechanisms as Drivers of Environmental Responses in Stony Corals

Ph.D. in Biology, Florida International University

Javier A. Rodriguez-Casariego

Dissertation — Exploring epigenetics as a tool for population assessment and conservation in large marine predators

Ph.D. in Biology, Florida International University

Andria P. Beal

80. Application of an improved chloroform-free lipid extraction method to staghorn coral (Acropora cervicornis) lipidomics assessments

Lugo Charriez K.***, Lemos L.S., Carrazana Y., Rodriguez-Casariego J.A.**, Eirin-Lopez J.M., Hauser-Davis R.A., Gardinali P., Soares Quinete N.

79. Genome-wide DNA methylation analysis reveals a conserved epigenetic response to seasonal environmental variation in the staghorn coral Acropora cervicornis

Rodriguez-Casariego J.**, Mercado-Molina A., Garcia-Souto D., Ortiz I.***, Lopes C., Baums I.B., Sabat A.M., and Eirin-Lopez J.M.

78. Deciphering the enigma of the histone H2A.Z-1/H2A.Z-2 isoforms. Novel insights and remaining questions

Cheema M.S., Soufari H., Kim B., O’Sullivan C., Good K.V., Freeman M.E., Stefanelli G., Rivera-Casas C.*, Zengeler K.E., Kennedy A.J., Eirin-Lopez J.M., Howard P.L., Zovkic I.B., Shabanowitz J., Dryhurst D.D., Hunt D.F., Mackereth C.D., and Ausio J.

77. Protamines from liverwort are produced by posttranslational cleavage and C-terminal di-aminopropanelation of several male germ–specific H1 histones

D’Ippolito R.A., Miamino N., Rivera-Casas C.*, Cheema M.S., Bai D.L., Kasinsky H.E., Shabanowitz J., Eirin-Lopez J.M., Ueda T., Hunt D.F., and Ausio J.

76. The Bottlenose dolphin Epigenetic Aging Tool (BEAT): a molecular age estimation tool for small cetaceans

Beal A.**, Kiszka J., Wells R., and J.M. Eirin-Lopez

75. Marine environmental epigenetics

Eirin-Lopez J.M., and H. Putnam

74. Seasonal DNA methylation variation in the flat tree oyster Isognomon alatus from a mangrove ecosystem in North Biscayne Bay, Florida

Suarez-Ulloa V.**, Rivera-Casas C.*, Michel M.***, and J. Eirin-Lopez

73. Coral epigenetic responses to nutrient stress: histone H2A.X phosphorylation dynamics and DNA methylation in the staghorn coral Acropora cervicornis

Rodriguez-Casariego J.**, Ladd M., Shantz A., Lopes C., Cheema M.S., Kim B., Roberts S., Fourqurean J.W., Ausio J., Burkepile D.E., and J. Eirin-Lopez

72. Karyotype characterization of nine periwinkle species (Gastropoda, Littorinidae)

Garcia-Souto D., Alonso S., Costa D., Eirin-Lopez J., Rolan-Alvarez E., Faria R., Galindo J., and J.J. Pasantes

71. Environmental epigenomics and its applications in marine organisms.

Beal A.**, Rodriguez-Casariego J.**, Rivera-Casas C.*, Suarez-Ulloa V.*, and J.M. Eirin-Lopez

70. Detection of invasive and cryptic species in marine mussels (Bivalvia, Mytilidae): A chromosomal perspective.

Garcia-Souto D., Sumner-Hempel D., Fervenza S., Perez-Garcia C., Torreiro A., Gonzalez-Romero R.*, Eirin-Lopez J.M., Moran P., and J.J. Pasantes

69. Molecular and biochemical methods useful for the epigenetic characterization of chromatin-associated proteins in bivalve molluscs.

Rivera-Casas C.**, Gonzalez-Romero R.*, Garduño R., Cheema M.S., Ausio J., and J.M. Eirin-Lopez.

68. Transcriptional and biochemical analysis of antioxidant enzymes in the mussel Mytilus galloprovincialis during experimental exposures to the toxic dinoflagellate Prorocentrum lima.

Prego-Faraldo V.**, Vieira L.R., Eirin-Lopez J.M., Mendez J., and L. Guilhermino.

67. Basic surface features of FKBPs facilitate chromatin binding.

Leung A., Jardim F.P., Savic N., Monneau Y.R., Gonzalez-Romero R.*, Gudavicius G., Eirin-Lopez J.M., Bartke T., Mackereth C.D., Ausio J., and C.J. Nelson.

66. Transcriptome profiling and differential gene expression in mussels exposed to Prorocentrum lima, a dinoflagellate producing DSP toxins.

Prego-Faraldo M.V.**, Florez-Barros F., Fernandez-Tajes J., Eirin-Lopez J.M., and J. Mendez

65. Effects of Florida Red Tides on histone variant expression and DNA methylation in the Eastern oyster Crassostrea virginica.

Gonzalez-Romero R.*, Suarez-Ulloa V.**, Rodriguez-Casariego J.**, Garcia-Souto D., Diaz G.***, Smith A., Pasantes J.J., Rand G., and J.M. Eirin-Lopez.

Dissertation — Transcriptomic and Epigenetic Responses to Environmental Stress in Marine Bivalves with a Focus on Harmful Algal Blooms

Ph.D. in Biology, Florida International University

M. Victoria Suarez-Ulloa

Dissertation — Characterization of Global DNA Methylation in Flat Tree Oysters (Isognomon alatus) and its Correlation with Environmental Abiotic Factors

Honors Degree in Biology, Florida International University

Michelot Michel

64. Network-inspired approaches for transcriptomic analyses.

IWBBIO Proceedings 2016:437-440. Aug. 2016

Aguiar-Pulido V., Suarez-Ulloa V.**, Eirin-Lopez J.M., and G. Narasimhan.

63. Unique yeast histone sequences influence octamer and nucleosome stability.

FEBS Letters 590:2629-2638. Aug. 2016. (IF = 3.52, Q1)

Leung A., Cheema M., Gonzalez-Romero R.*, Eirin-Lopez J.M., Ausio J., and C.J. Nelson.

62. Characterization of mussel H2A.Z.2: a new H2A.Z variant preferentially expressed in germinal tissues from Mytilus.

Biochemistry and Cell Biology 16:1-11. Jun. 2016. (IF = 2.15, Q2)

Rivera-Casas C.**, Gonzalez-Romero R.*, Vizoso-Vazquez A., Cheema M.S., Cerdan M.E., Mendez J., Ausio J., and J.M. Eirin-Lopez.

61. Early genotoxic and cytotoxic effects of the toxic dinoflagellate Prorocentrum lima in the mussel Mytilus galloprovincialis.

Toxins 8:159. May. 2016. (IF = 3.03, Q1)

Prego-Faraldo V.**, Valdiglesias V., Laffon B., Mendez J., and J.M. Eirin-Lopez.

60. The characterization of macroH2A beyond vertebrates supports an ancestral origin and conserved role for histone variants in chromatin.

Epigenetics 11:415-425. Apr. 2016. (IF = 5.11, Q1)

Rivera-Casas C.**, Gonzalez-Romero R.*, Cheema M.S., Ausio J., and J.M. Eirin-Lopez.

Dissertation — Assessment of the Early Effects of the Diarrhetic Shellfish Toxins in the Mussel Mytilus galloprovincialis: Using Cellular and Molecular Biomarkers 

Ph.D. in Biology, University of A Coruña (Spain)

M. Veronica Prego-Faraldo

59. Unbiased high-throughput characterization of mussel transcriptomic responses to sublethal concentrations of the biotoxin okadaic acid.

PeerJ 3:e1429. Nov. 2015. (IF = 2.84, Q1)

Suarez-Ulloa V.**, Fernandez-Tajes J., Aguiar-Pulido V., Prego-Faraldo V.**, Florez-Barros F., Sexto-Iglesias A., Mendez J., and J.M. Eirin-Lopez.

58. Environmental epigenetics: a promising venue for developing next-generation pollution biomonitoring tools in marine invertebrates.

Marine Pollution Bulletin 98:5-13. Sep. 2015. (IF = 3.01, Q1)

Suarez-Ulloa V.**, Gonzalez-Romero R.*, and J.M. Eirin-Lopez.

57. An unusual role for doublesex in sex determination in the dipteran Sciara.

Genetics 200:1181-1199. Aug. 2015. (IF = 3.79, Q1)

Ruiz M.F., Alvarez M., Eirin-Lopez J.M., Sarno F., Krimer L., Barbero J.L. and L. Sanchez.

56. In vitro analysis of early genotoxic and cytotoxic effects of okadaic acid in different cell types of the mussel Mytilus galloprovincialis.

Journal of Toxicology and Environmental Health, Part A 78:814-824. Jul. 2015. (IF = 2.67, Q1)

Prego-Faraldo M.V.**, Valdiglesias V., Laffon B., Eirin-Lopez J.M., and J. Mendez.

55. Computational Methods in Epigenetics.

pp. 154-175 in “Personalized Epigenetics”, edited by T. Tollefsbol, ed. Elsevier.

Aguiar-Pulido V., Suarez-Ulloa V.**, Eirin-Lopez J.M., Pereira J., and G. Narasimhan.

54. The comparative study of five sex determining proteins across insects unveils high rates of evolution at basal components of the sex determination cascade.

Development Genes and Evolution 225:23-30. Jan. 2015. (IF = 2.51, Q2)

Eirin-Lopez J.M., and L. Sanchez.

53. Evolution of High Mobility Group Nucleosome-binding (HMGN) proteins and its implications for vertebrate chromatin specialization.

Molecular Biology and Evolution 32:121-131. Jan. 2015. (IF = 13.64, Q1)

Gonzalez-Romero R.*, J.M. Eirin-Lopez, and J. Ausio.

Dissertation — Histone Variants in Marine Invertebrates: Methods for Chromatin Analysis and Characterization of macroH2A and H2A.Z.2 Variants in Bivalve Molluscs

Ph.D. in Biology, University of A Coruña (Spain)

Ciro Rivera-Casas

52. Characterization of histone variants in bivalve molluscs and their relevance in the development of chromatin-based tests for evaluating okadaic acid genotoxicity in the marine environment.

Biochemistry and Cell Biology 91:395-395. Dec. 2013. (IF = 1.52, Q4)

Gonzalez-Romero R.*, Rivera-Casas C.**, Mendez J., Eirin-Lopez J.M., and J. Ausio.

51. Bivalve omics: state of the art and potential applications for the biomonitoring of harmful marine compounds.

Marine Drugs 11:4390-4406. Nov. 2013. (IF = 3.51, Q1)

Suarez-Ulloa V.**, Fernandez-Tajes J., Manfrin C., Gerdol M., Venier P., and J.M. Eirin-Lopez.

50. Okadaic acid meet and greet: an insight into detection methods, response strategies and genotoxic effects in marine invertebrates.

Marine Drugs 11:2829-2845. Aug. 2013. (IF = 3.51, Q1)

Prego-Faraldo M.V.**, Valdiglesias V., Mendez J., and J.M. Eirin-Lopez.

49. Clustering of gene expression profiles applied to marine research.

IWANN 2013, Part I, Lecture Notes on Computer Science (LNCS) 7902: 453–462. Jun. 2013

Aguiar-Pulido V., Suarez-Ulloa V.**, Rivero D., Eirin-Lopez J.M., and J. Dorado.

48. The evolution of sex-related traits and genes 2012.

International Journal of Evolutionary Biology vol. 2013, Article ID 590769. Mar. 2013

Civetta A., Eirin-Lopez J.M., Kulathinal R., and J. Marshall.

47. The CHROMEVALOA database: a resource for the evaluation of okadaic acid contamination in the marine environment based on the chromatin-associated transcriptome of the mussel Mytilus galloprovincialis.

Marine Drugs 11:830-841. Mar. 2013. (IF = 3.51, Q1)

Suarez-Ulloa V.**, Fernandez-Tajes J., Aguiar-Pulido V., Rivera-Casas C.**, Gonzalez-Romero R.*, Ausio J., Mendez J., Dorado J., and J.M. Eirin-Lopez.

 46. About Evolution: keys to understanding how our genetic material evolves.

University of A Coruña Press, Spain

Eirin-Lopez J.M.

45. A computer lab exploring evolutionary aspects of chromatin structure and dynamics for an undergraduate chromatin course.

Biochemistry and Molecular Biology Education 41:95-102. Feb. 2013. (IF = 0.59, Q4)

Eirin-Lopez J.M.

44. The birth-and-death evolution of multigene families revisited.

pp. 170-196 in “Genome Dynamics vol. 7: Repetitive DNA”, edited by M.A. Garrido-Ramos. Karger, Switzerland

Eirin-Lopez J.M., Rebordinos L., Rooney A.P., and J. Rozas.

43. Vertebrate nucleoplasmin and NASP: egg histone storage proteins with multiple chaperone activity.

FASEB Journal 26:4788-4804. Dec. 2012. (IF = 5.70, Q1)

Finn R., Ellard K., Eirin-Lopez J.M., and J. Ausio.

42. Insights into the Study of Chromatin in Molluscs: Structure and Molecular Evolution of Histones in Pectinids.

EAE Press, Spain

Rivera-Casas C., Mendez J., and J.M. Eirin-Lopez

41. A unified phylogeny-based nomenclature for histone variants.

Epigenetics and Chromatin. 5:7. May. 2012. (IF = 4.19, Q1)

Talbert, P. B., K. Ahmad, G. Almouzni, J. Ausio, F. Berger, P.L. Bhalla, W.M. Bonner, W.Z. Cande , B.P. Chadwick, S.W.L. Chan, G.A.M. Cross, L. Cui, S.I. Dimitrov, D. Doenecke, J.M. Eirin-López, M.A. Gorovsky, S.B. Hake , B.A. Hamkalo, S. Holec, S.E. Jacobsen, K. Kamieniarz, S. Khochbin, A.G. Ladurner, D. Landsman, J.A. Latham, B. Loppin, H.S. Malik, W.F. Marzluff, J.R. Pehrson, J. Postberg, M. B Singh, R. Schneider, M.M. Smith, E. Thompson , M.E. Torres-Padilla, D.J. Tremethick, B.M. Turner, J.H. Waterborg , H. Wollmann, R. Yelagandula, B. Zhu, and S. Henikoff.

40. Chromatin specialization in bivalve molluscs: a leap forward for the evaluation of okadaic acid genotoxicity in the marine environment.

Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 155:175-181. Mar. 2012. (IF = 2.71, Q3)

Gonzalez-Romero R.**, Rivera-Casas C.**, Fernandez-Tajes J., Ausio J., Mendez J., and J.M. Eirin-Lopez.

39. Histone H2A (H2A.X and H2A.Z) variants in molluscs: molecular characterization and potential implications for chromatin dynamics.

PLoS ONE 7(1):e30006. Jan. 2012. (IF = 3.73, Q1)

Gonzalez-Romero R.**, Rivera-Casas C.**, Frehlick L.J., Mendez J., Ausio J., and J.M. Eirin-Lopez.

38. El papel clave de las histonas (The key role of histones)

Investigacion y Ciencia (Scientific American, Spanish edition). Dec. 2011

Gonzalez-Romero R.**, Ausio J., Mendez J., and J.M. Eirin-Lopez.

37. The evolution of sex-related traits and genes.

International Journal of Evolutionary Biology vol. 2011, Article ID 807218. Sep. 2011

Civetta A., Eirin-Lopez J.M., Kulathinal R., and J. Marshall.

36. Boule and the evolutionary origin of metazoan gametogenesis: a grandpa’s tale.

International Journal of Evolutionary Biology vol. 2011, Article ID 972457. Aug. 2011

Eirin-Lopez J.M. and J. Ausio.

35. Protamines: structural complexity, evolution and chromatin patterning.

Protein and Peptide Letters 18:755-771. Aug. 2011. (IF = 1.94, Q3)

Kasinsky H., Eirin-Lopez J.M., and J. Ausio.

Dissertation — A Molecular Database and Web Interface for Histone Variants in Molluscs

M.S. in Bioinformatics, International University of Andalusia (Spain)

M. Victoria Suarez-Ulloa

34. Birth-and-death long-term evolution promotes histone H2B variant diversification in the male germinal line.

Molecular Biology and Evolution 27:1802-1812. Aug. 2010. (IF = 5.51, Q1)

Gonzalez-Romero R.**, Rivera-Casas C.**, Ausio J., Mendez J., and J.M. Eirin-Lopez.

33. The gene transformer-2 of Anastrepha fruit flies (Diptera, Tephritidae) and its evolution in insects.

BMC Evolutionary Biology 10:140. May. 2010. (IF = 3.70, Q2)

Sarno F., Ruiz M.F., Eirin-Lopez J.M., Perondini A., Selivon D., and L. Sanchez.

32. Evolutionary dynamics of the 5S rDNA gene family in the mussel Mytilus: mixed effects of birth-and-death and concerted evolution.

Journal of Molecular Evolution 70:413-426. May. 2010. (IF = 2.31, Q3)

Freire R., Arias A., Insua A., Mendez J., and J.M. Eirin-Lopez.

31. H2A.Bbd: an X-chromosome-encoded histone involved in mammalian spermiogenesis.

Nucleic Acids Research 38:1780-1789. Mar. 2010. (IF = 7.84, Q1)

Ishibashi T., Li A., Eirin-Lopez J.M., Zhao M., Missiaen K., Abbott D.W., Meistrich M., Hendzel M.J., Hunt D.F. and J. Ausio.

Dissertation — Molecular Evolution of Histones in Metazoans: Implications for Chromatin Structure and Function in Bivalve Molluscs

Ph.D. in Biology, University of A Coruña (Spain)

Rodrigo Gonzalez-Romero

Dissertation — Characterization of Histone Genes in Pectinids: Structure and Molecular Evolution

M.S. in Biology, University of A Coruña (Spain)

Ciro Rivera-Casas

30. Characterization of H2A.Z-1 and H2A.Z-2 isoforms in vertebrates.

BMC Biology 7:86. Dec. 2009. (IF = 5.64, Q1)

Dryhurst D., Ishibashi T., Rose K.L., Eirin-Lopez J.M., McDonald D., Silva-Moreno B., Veldhoen N., Helbing C.C., Hendzel M.J., Shabanowitz J., and J. Ausio.

29. Origin and evolution of chromosomal sperm proteins.

Bioessays 31:1062-1070. Oct. 2009. (IF = 5.12, Q1)

Eirin-Lopez J.M., and J. Ausio.

28. Long-term evolution of histone families: old notions and new insights into their mechanisms of diversification across eukaryotes.

pp. 139-162 in “Evolutionary Biology: Concept, Modeling and Application”, edited by P. Pontarotti. Springer, Germany

Eirin-Lopez J.M., Gonzalez-Romero R.**, Dryhurst D., Mendez J., and J. Ausio.

27. Histone genes of the razor clam Solen marginatus unveil new aspects of linker histone evolution in protostomes.

Genome 52:597-607. Jul. 2009. (IF = 1.71, Q3)

Gonzalez-Romero R.**, Ausio J., Mendez J., and J.M. Eirin-Lopez.

26. The evolutionary differentiation of two histone H2A.Z variants in chordates (H2A.Z-1 and H2A.Z-2) is mediated by a stepwise mutation process that affects three amino acid residues.

BMC Evolutionary Biology 9:31. Feb. 2009. (IF = 4.29, Q1)

Eirin-Lopez J.M., Gonzalez-Romero R.**, Dryhurst D., Ishibashi T., and J. Ausio.

25. The sperm proteins from amphioxus mirror its basal position among chordates and redefine the origin of vertebrate protamines.

Molecular Biology and Evolution 25:1705-1713. Aug. 2008. (IF = 7.28, Q1)

Eirin-Lopez J.M., Frehlick L.J., Chiva M., Saperas N., and J. Ausio.

24. Early evolution of histone genes: prevalence of an ‘orphon’ H1 lineage in protostomes and birth-and-death process in the H2A family.

Journal of Molecular Evolution 66:505-518. May. 2008. (IF = 2.76, Q2)

Gonzalez-Romero R.**, Ausio J., Mendez J., and J.M. Eirin-Lopez.

23. Quickly evolving histones, nucleosome stability and chromatin folding: all about histone H2A.Bbd.

Gene 413:1-7. Apr. 2008. (IF = 2.58, Q3)

Gonzalez-Romero R.**, Mendez J., Ausio J., and J.M. Eirin-Lopez.

22. Insight into ligand diversity and novel biological roles for family 32 carbohydrate binding molecules.

Molecular Biology and Evolution 25:155-167. Jan. 2008. (IF = 7.28, Q1)

Abbott D.W., Eirin-Lopez J.M., and A. Boraston.

21. H2A.Bbd: a quickly evolving hypervariable mammalian histone that destabilizes nucleosomes in an acetylation-independent way.

FASEB Journal 22:316-326. Jan. 2008. (IF = 7.05, Q1)

Eirin-Lopez J.M., Ishibashi T., and J. Ausio.

20. The gene transformer of Anastrepha fruit flies (Diptera, Tephritidae) and its evolution in insects.

PLoS ONE 2:e1239. Nov. 2007. (IF = 4.35, Q1)

Ruiz M.F., Milano A., Salvemini N., Eirin-Lopez J.M., Perondini A.L., Selivon D., Polito C., Saccone G., and L. Sanchez.

19. The gene doublesex of Anastrepha fruit flies (Diptera, Tephritidae) and its evolution in insects.

Development, Genes and Evolution 217:725-731. Oct. 2007. (IF = 2.07, Q3)

Ruiz M.F., Eirin-Lopez J.M., Stefani R.N., Perondini A.L., Selivon D., and L. Sanchez.

18. Evolution of vertebrate chromosomal sperm proteins: implications for fertility and sperm competition.

pp. 63-79 in “Spermatology”, edited by E. R. S. Roldan and M. Gomendio. Nottingham University Press, United Kingdom.

Eirin-Lopez J.M., and J. Ausio.

17. Evolutions and revolutions of nuclear chaperones in chromatin remodeling: the nucleophosmin-nucleoplasmin family.

Biochemistry and Cell Biology 85:527-527. Aug. 2007. (IF = 2.42, Q3)

Eirin-Lopez J.M., and J. Ausio.

16. H2A.Z-mediated genome-wide chromatin specialization.

Current Genomics 8:59-66. Mar. 2007. (IF = 0.57, Q4)

Eirin-Lopez J.M., and J. Ausio.

15. New insights into the nucleophosmin/nucleoplasmin family of nuclear chaperones.

Bioessays 29:49-59. Jan. 2007. (IF = 5.40, Q1)

Frehlick L.J., Eirin-Lopez J.M., and J. Ausio.

Dissertation — Structure, Function, and Evolution of the Histone Multigene Family in the Veneridae group

M.S. in Biology, University of A Coruña (Spain)

Rodrigo Gonzalez-Romero

14. A unique histone H1-related protamine-like results in an unusual sperm chromatin organization.

FEBS Journal 273:4548-4561. Oct. 2006. (IF = 3.03, Q2)

Saperas N., Chiva M., Casas M.T., Campos J.L., Eirin-Lopez J.M., Frehlick L.J., Prieto C., Subirana J.A., and J. Ausio.

13. Histone H1 function and distribution in chromatin: what does molecular evolution tell us about it?

Biochemistry and Cell Biology 84:658-658. Aug. 2006. (IF = 3.48, Q2)

Eirin-Lopez J.M., and J. Ausio.

12. Long-term evolution and functional diversification in the members of the nucleophosmin/nucleoplasmin family of nuclear chaperones.

Genetics 173:1835-1850. Aug. 2006. (IF = 4.24, Q1)

Eirin-Lopez J.M., Frehlick L.J., and J. Ausio.

11. The characterization of amphibian nucleoplasmins yields new insight into their role in sperm chromatin remodeling.

BMC Genomics 7:99. Apr. 2006. (IF = 4.03, Q1)

Frehlick L.J., Eirin-Lopez J.M., Field E.D., Hunt D.F., and J. Ausio.

10. Common phylogenetic origin of protamine-like (PL) proteins and histone H1: evidence from bivalve PL genes.

Molecular Biology and Evolution 23:1304-1317. Jun. 2006. (IF = 6.73, Q1)

Eirin-Lopez J.M., Lewis J.D., Howe L.A., and J. Ausio.

9. Presence of protamines in the sperm of two closely related species of Scorpaeniform fish with internal (Sebastes maliger) and external (Sebastolobus sp.) sexual reproduction.

Journal of Experimental Zoology. Part A, Comparative Experimental Biology 305:277-287. Mar. 2006. (IF = 1.35, Q2)

Frehlick L.J., Eirin-Lopez J.M., Prado A., Su H.W., Kasinsky H.E., and J. Ausio.

8. Protamines, in the footsteps of linker histone evolution.

Journal of Biological Chemistry 281:1-4. Jan. 2006. (IF = 5.81, Q1)

Eirin-Lopez J.M., Frehlick L.J., and J. Ausio.

7. H2AX: tailoring histone H2A for chromatin dependent genomic integrity.

Biochemistry and Cell Biology 83:505-515. Aug. 2005. (IF = 2.87, Q2)

Li A., Eirin-Lopez J.M., and J. Ausio.

6. Common evolutionary origin and birth-and-death process in the replication independent histone H1 isoforms from vertebrate and invertebrate genomes.

Journal of Molecular Evolution 61:398-407. Sept. 2005. (IF = 2.70, Q2)

Eirin-Lopez J.M., Ruiz M.F., Gonzalez-Tizon A.M., Martinez A., Ausio J., Sanchez L., and J. Mendez.

Dissertation — Characterization of Histone Genes in the Mussel Mytilus and Molecular Evolution of the Histone H1 Multigene Family

Ph.D. in Biology, University of A Coruña (Spain)

Jose M. Eirin-Lopez

5. The gene sex-lethal of the Sciaridae family (Order Diptera, Suborder Nematocera) and its phylogeny in dipteran insects.

Genetics 168:907-921. Oct. 2004. (IF = 4.14, Q1)

Serna E., Gorab E., Ruiz M.F., Goday C., Eirin-Lopez J.M., and L. Sanchez.

4. Birth-and-death evolution with strong purifying selection in the histone H1 multigene family and the origin of “orphon” H1 genes.

Molecular Biology and Evolution 21:1992-2003. Oct. 2004. (IF = 6.35, Q1)

Eirin-Lopez J.M., Gonzalez-Tizon A.M., Martinez A., and J. Mendez.

3. Molecular evolutionary analysis of the mussel Mytilus histone multigene family: first record of a tandemly repeated unit of five histone genes containing an H1 subtype with “orphon” features.

Journal of Molecular Evolution 58:131-144. Feb. 2004. (IF = 2.75, Q2)

Eirin-Lopez J. M., Ruiz M.F., Gonzalez-Tizon A. M., Martinez A., Sanchez L. and J. Mendez.

2. Molecular and evolutionary analysis of mussel histone genes (Mytilus spp.): possible evidence of an “orphon” origin for H1 histone genes.

Journal of Molecular Evolution 55:272-283. Sept. 2002. (IF = 3.04, Q2)

Eirin-Lopez J.M., Gonzalez-Tizon A.M., Martinez A., and J. Mendez.

1. Molecular, phylogenetic and evolutionary study of histone H1 and H3 genes: molecular markers in marine biology and aquaculture.

pp. 52-62 in “5th Meeting of Young Researchers”. Xunta de Galicia, Spain.

Eirin-Lopez J.M.